Ronald B. Keys, JD, PhD
Free Initial Consultation Call: (954) 448-1515 E-mail: email@rkeysphd.com |
 |
 |
Free Initial Consultation - Call Now (954) 448-1515 SYSTEMS HORMONE REPLACEMENT - HRT & BIO-IDENTICAL HORMONES (BIH) Understanding the big picture... Sexual differrentiation is a process by which the primary and secondary sexual characteristics of males and female develop and distinquish themselves from each other among primates. This develpmental process throughout the human life span takes place and may be described as three phrases. 1. Differentiation, in youth but most dramatically at puberty 2. De-differentiation, where developmental differences disappear late in life 3. Re-differentiation, .where these characteristics are regenerated and orchestrated, carefully, through systems based hormone replacement and connected hormone therapeutics. With the man, his gonads may shrink (hypogonadism) and he may develop breasts on his chest (gynecomastia) when he de-differentiates. His angularity turns into roundness. His body shifts from predominance in lean body mass LBM) to fat mass (FM). His androgen to estrogen inversion in particular may be evident in his blood chemistry. The estrogen levels have climbed and testosterone levels have dropped. This is called the androgen to estrogen inversion and is reflected in his measured, clinical biochemistry to corroborate with the changes in his physical appearance. With the woman, her breasts and vagina may shrink in size and vaginal dryness may become increasingly evident.. Her roundness and curves may turn angular and boxlike in overall form and presentation. While the man may look like a snowman, the woman may appear like a walking refrigerator box. There may be an androgen to estrogen inversion here also, when estrogen levels have dropped and androgen level increased. This is objectified and correlated in her clinical biochemistry. . A couple may easily present sitting next to each other where the wife?s androgen levels are higher than her mates? level., while he has higher estrogen levels than his mate next to him. They start to look alike. This has been seen commonly in human experience of simple observation. Outwardly, the way one tells the difference between the two is when the woman may wear a bow in her hair and a two piece bathing suit while the man may wear a one piece bathing suit. In every day terms, this is de-differentiation. A systems replacement in hormone therapeutics recognizes that all hormone systems work together to create sexual differentiation and re-differentiation.in the elderly. This is not a narcissistic exercise for personal vanity because de-differentiation as a process parallels developmental declines and loss of range of function and quality of life. Hormone deficits not only affect curves and angularity but also the mental and cognitive state. Low testosterone levels have been associated with passive aggressive behavior and depression...loss of a sense or willingness for mastery and adaption. The same is true with measured, proven deficiencies in human growth hormone, called adult human growth hormone deficiency syndrome. There are mental and behavioral correlates to growing decreases and loss of function due to aging. Mind and body are one. Isolating a single hormonal system.and ignoring all of the others is a mistake. Creating imbalance this way is a bit like driving down the street in a car with wheel mallallignment and different air pressure in your tires. The ride is not a smooth one and it may be dangerous. The same is true with HRT that ignores adjustments in all hormone systems at the same time. An empirical approach: measured depletion-measured repletion If engine oil in a car was dipsticked and re-dipsticked and found to be 5 quarts low, taken together with a red light flashing on the dashboard of an engine overheat and even smoke coming out from underneath the car hood, certain routine conclusions may be formed in most cases. The conclusions are that engine oil is needed and in the amount of 5 quarts. This is only an analogy. But it is evidence based auto-mechanics 101. In most cases these conclusions are both rational and empirical. Other fluid levcels are also checked. There is no opinion evidence. In most cases, it is empirical fact. Same is true in systems hormone replacements If you are 5 quarts measured low on engine oil, it is insane to put in 8 quarts that would spill 3 quarts all over your driveway. 5 quarts are put in to restore (replete) the 5 quarts that are missing (depleted). By dipsticking what you are doing, it is impossible to put in too much. True systems HRT replaces measured depletion to a measured repletion or measured restoration of hormone levels to a usual 35 year old analytical biochemistry hormone assay target range. There is more to this, of course, but that is the purpose of a consult with Dr. Keys. Dr. Keys? work, as a consulting, internet-based, online PhD, is to guide your treatment .with your local physician into proper and detailed empirical study for rational, detailed, focused, diagnosis and treatment. We don?t speculate and surmise nor are opinions offered. The numbers from the biochemistries may jump out and yell at you like smoke from the engine in the car analogy.. . What hormones should be measured and what does the pattern recognition and the clusters on the numbers of the biochemistries show and depict in each case? How is it relevant to this patient?s history? Should tumor marker study be done and what tumor markers may be appropriate based upon the patient and family history? purpose of systems approached HRT It is part of the framework of restoring 1. range of function 2. Quality of life What is sought is to re-estrogenize the female and to restore otherwise her identity as a sexual and female person. She may need to be de-androgenized. Likewise, the male may require prescribed estrogen blockade to de-estrogenize him while he is re-androgenized. This is correction of a measured, androgen to estrogen inversion in both cases. Roundness may be restored to the female reversing her angularity while angularity is returned to the male to reverse his roundness. This is not for narcissism and vanity but for functional enhancement, range of motion and quality of life. Remember that multiple hormones work at the same time together. This not a one song only estrogen progestin story and may include thyroid function study, DHEA, HGH, pregnenolone, progesterone, testosterone, melatonin, cortisol, insulin and other hormone systems. It includes standard blood chemistry also but may require lipid peroxide study, amino acid, essential fatty acid, organic acid biochemistries and more. This is only a quick summary or landscape here and not intended for exhaustive detail. Bio-identical hormone therapy (BIHT, only); you can't fool mother nature Bio-identical hormones (BIH) are plant-derived and bio-identical to endogenous hormones. They may be acquired from special sources or compounding pharmacies and in any dose that may be clinically requested. They may be used in lower doses and thought to metabolize differently in the body then non-bio-identical hormones. They may have a shorter half-life and used in customized dosing regimens and in potencies that fit each person and clinical situation; one size does not fit all. The idea is to adjust the dosing to higher doses or smaller or weaker in smaller units when going off or onto them. There is no sledge-hammer application here but rather efforts for evidence-based therapeutic enhancements. The hypothesis here is that non-bio-identical hormones may act like a constant environmental toxin to the genetic material within the cell; even though it can bind to the receptor hormone complex, it is a foreign substance. All cancers stem from special mutation beyond ordinary errors in translation or errors in transcription in DNA replication. What is the impact of a non-bio-identical hormone on mutation and on the day to day function of major gene cluster regulatory systems in a clinical genetics model? Many people believe that there is a profound distinction between a non-bio-identical hormone (NBIH) and a bio-identical hormone (BIH) with distinct metabolic footprints, consequences and clinical outcomes on the rest of the body for each one. Is a NBIH distinctly cytotoxic to sensitive tissues, or may they alter binding of other hormones to those receptors or alter the liver's metabolism and detoxification of carcinogens? Bio-identical hormones (BIH) may come from special sources, special pharmacies and in any dose or combination and are available without the preservatives, adhesives, dyes, binders and fillers found in the limited dosing options available from regular pharmaceutical companies. You can't fool mother nature, or can you? Think about it. This is not an academic exercise and clinical guidance for specific protocols may be developed for you. When and how do you apply a BIH? Bio-identical hormones (BIH) should be applied to profoundly mimic the actual, secretory patterns of the patient's past, hormone life and current internal regulatory environment. What is the patient's past patterns of normal endogenous hormone outputs? What is the circadian history and current biology of this patient? Timing is everything!!!! Free Initial Consultation - Call Now (954) 448-1515 RONALD B. KEYS, JD, PhD CLINICAL & OPERATIONS DIRECTOR Ronald B. Keys, JD, PhD 2402 N. 28th Avenue Hollywood, Florida, 33020-1814 USA 954-448-1515 primary email: email@rkeysphd.com secondary email: rkeysphd@brainlink.com secondary email: rkeysphd@yahoo.com by pre-arrangements for voice/text chat: Mostly, Dr. Keys works as a Consulting PhD Doctor, usually from a distance, with and through a proper local anchor physician to order blood work. Advanced treatment protocols may develop from the advanced blood chemistries he requests. If you have no local doctor, Dr. Keys finds one through an affiliate physician network. His work is global, oftetimes involving patients from other countries as well as all over the continental USA. There are many tests and treatments to help people; Oftentimes, anchor physicians are not familiar or comfortable with them. Dr. Keys teaches and helps to direct individual patients AND their physicians with laboratory-work for these treatment options. This is measured work and clinical biochemistry. Opinion evidence standards are not employed here since this is a measured and laboratory-based or empirical study of the patient. Numbers are sought from the results of these tests that, usually, "...jump up and grab you..." that dictate what is needed and how much. Patient-advocacy is frequently involved to get advanced and necessary clinical biochemistries ordered and to help interpret them in filed reports..Chat room capabilities in voice or text, besides email, may be employed. This may include conference calls online. In a perfect world, if your physician knew everything, people like Dr. Keys would not exist. Physicians themselves are caught frequently in the traps of their own standards of care that may be very limited in many cases. Methods used by Dr. Keys are rational, scientific and disciplined. Designed by Fencl Web Design.Com DISCLAIMER: Ronald B. Keys, JD, PhD is not a physican. He acts here, when hired, only as a consulting PhD doctor. Any information offered on this site is intended for prevention and education. It is the responsibility of your anchor doctor or chosen physician to diagnose and treat diseases through their medical licenses. By using this web site you agree that you will seek professional medical advice from your doctor before using any of the information presented on this web site. All tests are ordered through your physician, only, and not Dr. Keys. Most jurisdictions require that an attending physician is required by law to take patient and family history, conduct a physical examination of the patient and to order tests appropriate and necessary. As an online consultant, he cannot do these things required together, as a whole, as a practice of medicine. Any emergencies should only be handled in a hospital emergency room or by your physician. |