Ronald B. Keys, JD, PhD
Free Initial Consultation Call: (954) 448-1515 E-mail: email@rkeysphd.com |
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Free Initial Consultation - Call Now (954) 448-1515 Immunological Perspectives Why additional tests may be appropriate......... ALTERED STATES OF METABOLISM The basic notion is to identify and profile altered states of metabolism in the patient, a functional approach, rather than identification and classification under ICD-9-CM (International Classification of Diseases, 9th Revision, Clinical Modification Codes). Using advanced molecular diagnostics, beyond morphology, structure and function, analyte, solute and metabolite patterns are examined so that a management protocol may fit the patient like pieces of a puzzle. New capabilities have been created by molecular biology, novel instrumentation and information technologies that may now be brought together to allow a better understanding of this patient's white blood cell system at molecular and cellular levels. In this way, we may better characterize her immune system structures, functional units and metabolic pathways to upregulate or improve existing levels of function. There are hundreds of biochemical reactions and dozens of metabolic pathways,circuits and loops that mediate the immunohistochemical reserves, capacities and capabilities of this patient. A comprehensive approach is to reach clinical thresholds by finding the right combination to activate DNA-RNA pathways to code both for the production and proliferation of all necessary white blood cell subsets. The rate of tumor progression, and or precancerous lesions is affected by the immunohistochemical reserves, capacities and capabilities of the patient at any given time; it is not fixed and immutable. The requested tests are designed to identify and profile existing biochemical pathways within this patient so that an individualized protocol may be developed consistent with this patient's existing biochemistry, not wishful thinking or cookbook medicine approaches. GLUTATHIONE LEVELS MEDIATING IMMUNE RESPONSES For example, functional plasma glutathione levels may be a critical factor in the immunohistochemical responses of the patient. Glutathione (GSH) is a central player in the antioxidant defense system. It is a tripeptide (3-ammino-acid protein) made from glutamate, cysteine and glycine. The active site on the glutathione molecule is the sulfhydryl (SH) group on the cysteine part of the glutathione (which is where the "SH" comes from in the GSH. The sulhydryl group (sometimes called a thiol group) interacts with a free radical to form a glutathione radical, which dimerizes (pairs up with another glutathione radical) to form oxidized glutathione (GSSG). The oxidized glutathione is then recycled back to glutathione for reuse. The maintenance of reduced glutathione appears to be especially critical for basic health and vitality. Glutathione levels are measured as a key organic acid within the ION panel by Metametrix Laboratory. The ION Panel is an advanced clinical biochemistry that profi BEYOND DISEASES CLASSIFICATION: UNDERLYING BIOCHEMICAL PATHWAYS The questions that need to be asked, beyond classification under ICD-9-CM (International Classification of Diseases, 9th Revision, Clinical Modification Codes) are 1. What is the internal environment of this patient? What is the character and cellular architecture of any lesions, if present? 2. What co-factors are needed to upregulate (upgrade) the patient's immunohistochemical reserves, capacities and capabilities (persistent cough, etc)? 3. What is the patient's altered state of metabolism, if any? Immune system compromise and assessment of immunohistochemical reserves in a given patient cuts across most diagnostic ICD-9-CM Code classifications. The current approach to infectious, neoplastic and autoimmunologic disease management emphasizes chemotherapy with the usual potential for adverse drug reactions, side effects, drug tolerances and other limitations. The emergence of antibiotic-resistant strains of bacteria, as well as difficult to treat new viral and zoonotic diseases and other pathogens known as "stealth pathogens" that pass "underneath the body's radar defense systems" argues for a reassessment of current therapies and the development and transfer of new biotechnologies into mainstream clinical practice. Clinical assessment should include effective, practical and even less expensive and less hi-tech treatment options that are far beyond the current system of practitioners many of whom may be locked into limited clinical practice guidelines and treatment choices largel The program objectives when a live patient faces us is to identify and review a wide range of factors that impact the patient's immune system performance, with a view toward effective and practical intervention strategies. Special attention should be given to (1) the role of nutrition in immune system modulation; (2) adjunctive strategies for treatment of refractory diseases like Chronic Fatigue Syndrome, Cancer, Lyme Disease and AIDS; (3) Open minded and novel prospectives in antimicrobial therapy such as for use in autoimmune disease; (4) the role of biobotanical or phytonutrients as immune system modulators; (5) the psychoneuroimmunology dimensions and depths of disease; (6) the techniques of assessing the immune system; (7) innovative methods for biological response modification with appropriate biobehavioral modification; (8) the role of screening for environmental toxins on the immune system and techniques of mitigating their effect; and (9) the identification of increasingly n THE ROLE OF TOXINS Toxins are a major factor in the increase of degenerative conditions and diseases; pollutants and toxins accelerate the aging process. Basic concepts must be understood by the patient in treating toxic states. A toxin has been defined as any class of more or less unstable poisonous compounds elaborated by animal, vegetable or bacterial organisms and acting as causative agents in many diseases, usually after an incubation period; its action may be subclinical and give rise to compromises in healthy function prior to formal onset of disease. Immunotoxicology is the science of the delicate and precise relationship between levels of immune function and the origins, nature, properties and effects of poisons, of their detection in the organs or tissues, of their antidotes and removal in the treatment of subclinical conditions and diseases due to poisoning. Most people are unaware that toxins, chemicals and pollutants that infect our internal environment are behind the massive increase in cancer, especially breast cancer. A study involving the analysis of a great number of frozen lumps from a "lumpectomy" surgical center showed that these lumps were a veritable waste dump of highly toxic pollutants. The women had been exposed to these chemical slow acting poisons unwittingly, years before the onset of symptoms. The toxins were stored in fatty tissues in a futile effort by the body to wall off the poisons, and then breast cancer developed. Mainstream, crisis oriented medicine then deals with the malignant tumor with a radiation accelerator machine. This adds even more toxins to the body in the form of intravenous chemotherapy. The storage of toxins in human tissue is like a time bomb waiting to go off. Most human cancers develop through a process of evolution within the tissue microenvironment. In tumor dormancy, sometimes called "the quiet before the storm," the tumors may maintain their size over many years or even decades, without additional growth; then suddenly, they "awaken" followed by rapid tumor growth and proliferation called the "cancer cascade." Intake of dietary fat and many other factors may modulate tumor angiogenesis by influencing tumor dormancy. Responsible clinical practice involves the identification of immediate "triggers" and "mediators" as well as "antecedent conditions," genetic or otherwise, in the patient's life that may influence tumor dormancy. A tumor either stays the same, shrinks or goes wild in the cancer cascade. Every patient passing through Dr. Keys's office is a special person who is screened for immunotoxicological insult for the presence of toxic signs, symptoms or tis AN INTEGRATED APPROACH This integrated approach is compared with the seductive and simple-mindedness of hi-tech gadgetry in clinical medicine; expansion of intellectual and conceptual approaches is necessary for cancer and other immune related illnesses. There is the standard acceptance and use of highly impressive looking pieces of medical equipment; frequently, this technology is so impressive looking that the clinician stops asking basic and fundamental questions. (1) Should this machine be used? (2) If so, for whom? (3) If so, for how long? (4) And at what cost, both from a cytoxoic (cell-destroying) as well as economic, cost-benefit prospective? Instead, the clinician only asks, "How do I hook it up?" Free Initial Consultation - Call Now (954) 448-1515 RONALD B. KEYS, JD, PhD CLINICAL & OPERATIONS DIRECTOR Ronald B. Keys, JD, PhD 2402 N. 28th Avenue Hollywood, Florida, 33020-1814 USA 954-448-1515 primary email: email@rkeysphd.com secondary email: rkeysphd@brainlink.com secondary email: rkeysphd@yahoo.com by pre-arrangements for voice/text chat: Mostly, Dr. Keys works as a Consulting PhD Doctor, usually from a distance, with and through a proper local anchor physician to order blood work. Advanced treatment protocols may develop from the advanced blood chemistries he requests. If you have no local doctor, Dr. Keys finds one through an affiliate physician network. His work is global, oftetimes involving patients from other countries as well as all over the continental USA. There are many tests and treatments to help people; Oftentimes, anchor physicians are not familiar or comfortable with them. Dr. Keys teaches and helps to direct individual patients AND their physicians with laboratory-work for these treatment options. This is measured work and clinical biochemistry. Opinion evidence standards are not employed here since this is a measured and laboratory-based or empirical study of the patient. Numbers are sought from the results of these tests that, usually, "...jump up and grab you..." that dictate what is needed and how much. Patient-advocacy is frequently involved to get advanced and necessary clinical biochemistries ordered and to help interpret them in filed reports..Chat room capabilities in voice or text, besides email, may be employed. This may include conference calls online. In a perfect world, if your physician knew everything, people like Dr. Keys would not exist. Physicians themselves are caught frequently in the traps of their own standards of care that may be very limited in many cases. Methods used by Dr. Keys are rational, scientific and disciplined. Designed by Fencl Web Design.Com DISCLAIMER: Ronald B. Keys, JD, PhD is not a physican. He acts here, when hired, only as a consulting PhD doctor. Any information offered on this site is intended for prevention and education. It is the responsibility of your anchor doctor or chosen physician to diagnose and treat diseases through their medical licenses. By using this web site you agree that you will seek professional medical advice from your doctor before using any of the information presented on this web site. All tests are ordered through your physician, only, and not Dr. Keys. Most jurisdictions require that an attending physician is required by law to take patient and family history, conduct a physical examination of the patient and to order tests appropriate and necessary. As an online consultant, he cannot do these things required together, as a whole, as a practice of medicine. Any emergencies should only be handled in a hospital emergency room or by your physician. |